Retraining the injured spinal cord

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Retraining the injured spinal cord.

The present review presents a series of concepts that may be useful in developing rehabilitative strategies to enhance recovery of posture and locomotion following spinal cord injury. First, the loss of supraspinal input results in a marked change in the functional efficacy of the remaining synapses and neurons of intraspinal and peripheral afferent (dorsal root ganglion) origin. Second, follow...

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Topical Review Retraining the injured spinal cord

reorganization of the sensorimotor pathways occurs caudal to the lesion. Some of these changes are inevitable just from the loss of some or all descending fibres. Synapses on the membranes of interneurones, motoneurones and, perhaps, propriospinal neurones may change in number, size and distribution. Any of these alterations can contribute to changes in the efficacy of neuronal input. Even with...

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Spinal Cord-Injured Rats

Opérant conditioning of the spinal stretch reflex or its electrical analog, the H-reflex, is a new model for exploring the mechanisms of long-term supraspinal control over spinal cord function. Primates and rats can gradually increase (HRup conditioning mode) or decrease (HRdown conditioning mode) the H-reflex when reward is based on H-reflex amplitude. An earlier study indicated that HRdown co...

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A Robotic Stepper for Retraining Locomotion in Spinal-Injured Rodents

We describe the design and testing of a robotic system to assist locomotion training of spinal-injured rodents. The goal of the system is to control and quantify spatialtemporal patterns of movement and forces during the stance and swing phases of rat locomotion. This approach will allow us to provide varying levels of assistance to limb movement during stepping and to quantify the effects of a...

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Insights From Spinal Cord–Injured Humans

Background—We studied the role of the central nervous system, neural feedback from contracting skeletal muscles, and sympathetic activity to the heart in the control of heart rate and blood pressure during 2 levels of dynamic exercise. Methods and Results—Spinal cord–injured individuals (SCI) with (paraplegia, n 4) or without (tetraplegia, n 6) sympathetic innervation to the heart performed ele...

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ژورنال

عنوان ژورنال: The Journal of Physiology

سال: 2001

ISSN: 0022-3751,1469-7793

DOI: 10.1111/j.1469-7793.2001.0015b.x